كتاب Comparative efficacy of diminazene diaceturate and imidocarb dipropionate against Babesia equi infection in donkeys

Comparative efficacy of diminazene diaceturate and imidocarb dipropionate against Babesia equi infection in donkeys من كتب طب بيطرى ABSTRACT Singh, B., Banerjee, D.P. and Gautam, O.P., 1980. Comparative efficacy of diminazene di- aceturate and imidocarb dipropionate against Babesia equi infection in donkeys. Vet. Parasitol., 7: 173--179. Diminazene diaceturate (Berenil, Hoechst) at 12 mg/kg intramuscularly (i/m) and re- peated after 24 hours controlled the rising parasitaemia of Babesia equi infection in four out of five splenectomised donkeys. The drug was more effective in the early stages of the disease and had a prophylactic effect for at least 30--35 days. A new babesicide, imidocarb (Imizol, Burroughs Wellcome), was 100% effective in three splenectomised donkeys at 5 mg/kg, i/m and repeated after 48 hours. However, imidocarb at 5 or 2 mg/kg i/m with a single injection was only partially effective or ineffective. INTRODUCTION The list of drugs against equine babesiosis includes trypan blue, Acaprin, Babesan, Pirevan, euflavin, phenamidine, quinine dihydrochloride, Berenil, oxytetracycline and others (Kirkham, 1969), but none are as effective against B. equi as they are against the large babesia B. caballi. Most of the drugs im- prove the clinical signs but do not completely eliminate the infection. Practi- cal disease-control measures can usefully be undertaken with a drug that will completely eliminate the infection. The present investigations deal with the therapeutic activities of diminazene diaceturate and imidocarb dipropionate against experimental B. equi infec- tion in splenectomised donkeys.
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