كتاب Optional ortho and lateral lithiations of4,4dimethyl2(otolyl)oxazolines

Abstract—4,4-Dimethyl-2-(o-tolyl)oxazolines 1 undergo normal lateral lithiation at the benzylic position by treatment with sec-BuLi in diethyl ether at −78°C. In contrast, metalation of 1 with sec-BuLi/TMEDA in diethyl ether at the same temperature leads to ortho-lithiation at the 6-position. Rationalization for the unusual ortho-lithiation of 1 is proposed. © 2002 Elsevier Science Ltd. All rights reserved.
Naruki Tahara, Tsutomu Fukuda and Masatomo Iwao - ❰ له مجموعة من الإنجازات والمؤلفات أبرزها ❞ Optional ortho and lateral lithiations of4,4dimethyl2(otolyl)oxazolines ❝ ❞ Synthesis of 3 substituted 8 hydroxy 3,4 dihydroisocoumarins ❝ ❱
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